What Are Phase 2b Clinical Trials?

Clinical Trials What Are Phase 2b Clinical Trials?

2b or Not 2b—DoNotPay Helps With the Phase 2b Clinical Trial Dilemma

Clinical trials are an essential part of modern medicine. New drugs and procedures can’t be introduced without extensive testing. Animal studies can only help us learn so much, which is why human test subjects are mandatory for clinical research.  

The different phases of clinical trials play a crucial role in determining the defining characteristics of new treatments. The second phase of testing focuses on the efficacy of a particular drug or procedure. 

If you’re looking for a quick and convenient way to find clinical trials or medical surveys near you, DoNotPay has exactly what you need. 


Why Should I Join a Clinical Trial?

There’s no simple answer to this question, as there are plenty of factors that can motivate you to participate in clinical trials

  1. Contributing to science—Clinical trials are the cornerstone of medical progress. Without human test subjects, medical advancements would slow down to a crawl. The fact that you made a meaningful contribution to science can be a reward in itself
  2. Receiving compensation—Finding volunteers that will put their health on the line for science presents a challenge for researchers. Incentives, such as payment or medical expense coverage, attract more human test subjects. Paid clinical trials for healthy volunteers represent a good opportunity to make money and help medicine. Some research centers offer up to $10,000 per clinical trial
  3. Getting better treatment options—Clinical trial participants that suffer from the tested illness can use this opportunity to see if the new treatment will help them. Later phases of a trial will focus on comparing the new treatment with older ones. If the participant is lucky, they may experience improvement during the trial
  4. Receiving more advanced care—Researchers must pay close attention to participants’ health to make sure that there are no serious complications as a result of testing. This means that volunteers will receive the best medical care and monitoring during the clinical trial. Best of all, research centers cover the costs of medical care in most cases

The Different Phases of Clinical Trials

It’s impossible to define clinical trials without mentioning their phasic nature. 

Medical treatments must go through several phases of clinical trials before they can be approved for general use. These phases have two goals:

  • Demonstrating the efficacy of the drug or procedure compared to existing treatment options
  • Showing that the medical benefits of the treatment outweigh its adverse effects

While they do share a common goal, each trial has a different priority. Here’s an overview of how they work:

Clinical Trial Phase Number of Participants Focus
Phase 0 10–15
  • Gathering preliminary data about drug pharmacokinetics
  • Speeding up the development of treatments that show promise
Phase I 20–100
  • Assessing the safety and tolerability of new treatment options
  • Increasing doses of drugs under 24/7 medical supervision
  • Determining a safe dose or dose range
Phase II 50–300
  • Evaluating the biological activity of new drugs
  • Assessing the efficacy of the tested treatment
Phase III 300–3000
  • Determining the value of the new treatment, compared to existing options
  • Obtaining additional safety and efficacy data
Phase IV All patients that seek treatment
  • Monitoring the long-term side effects of marketed drugs
  • Finding new applications for approved treatments

What Are Phase IIb Clinical Trials?

Phase II has two sub-stages that focus on different aspects of the treatment being tested. There’s no exact line that separates these stages, as they both aim to test the safety and efficacy of new drugs and medical procedures. 

What makes Phase IIb specific is that researchers know that the drug has desired biological effects when administered to human subjects. Phase II trials are generally safer than phases 0 and I, as the treatment has been tested for safe dosages. While this may provide comfort for participants, it also means that the trials offer less compensation. 

The main purpose of Phase IIb trials is to find an optimal dose that causes minimal side effects while still retaining the desired therapeutic function. 

Phase IIb can be considered an interim step towards Phase III of clinical research. The drug or procedure is rigorously tested for its efficiency in treating, preventing, or diagnosing a disease. The key difference between Phase IIb and Phase III is that the drug is not compared to existing treatments. 

What’s the Difference Between Phase 2a and 2b Clinical Trials?

Prospective volunteers may be confused when they come across Phase II sub-stages during the application process. As there are no formal definitions for clinical trial phases IIa and IIb, research centers may define them differently. 

Phase IIa usually marks tests that try to determine the drug’s biological activity. While phase I takes a look at the minimum and safe dosages that can be administered, Phase IIa proves whether or not there’s a dose-response relationship and to what extent. 

How Can DoNotPay Help Me Join Phase IIa and IIb Clinical Trials?

Looking for a clinical trial can be challenging. Most people will google “clinical trials near me” and hope it will display appropriate trials. Search engines and medical research websites can only do so much if you don’t know exactly where to look. 

DoNotPay helps solve this problem by simplifying the search process. Our app has an extensive database of clinical trials that is easy to navigate. You can use our clinical trial search feature to filter trials by phase, making it easier to focus on Phase IIb trials. Here’s how we can help you join a clinical trial:

  1. Access DoNotPay from your web browser
  2. Navigate to the Clinical Trials section
  3. Press Get Started
  4. Set up search parameters that will narrow down the results
  5. Select a study and click on Contact

DoNotPay will contact the research center on your behalf. If one of your desired trials isn’t recruiting yet—don’t worry! You can keep tabs on trial in question with our bookmarking feature. Once they have an opening, we’ll make sure to notify you.

Even if we help you find a paid clinical trial, you don’t have to worry about giving us a cut—you get to keep every cent you make. 

Where Else Can I Find a Phase IIb Clinical Trial?

Numerous online resources can help you find clinical trials that suit your needs. They might not be simple to navigate if you’re looking for something specific, but they can provide a lot of useful information. Here are some sources you might want to check out:

DoNotPay—Finding Clinical Trials & Much More

If you want to participate in clinical trials in Boston, Houston, or anywhere else in the U.S., DoNotPay has your back. You can use our app to locate medical research of any kind. Finding clinical trials for MS or depression is easy when you have our app on your side. 

Many paid clinical trials for healthy volunteers also offer coverage of medical expenses. If the trial you choose doesn’t pay enough, DoNotPay can show you how to get help with medical bills. 

To start using our app’s many features, open DoNotPay in your web browser and take a look at all the mundane tasks we can simplify:


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