Pain Management Clinical Trials Explained

Clinical Trials Pain Management Clinical Trials Explained

What Are the Best Pain Management Clinical Trials in the U.S.?

Over 50 million Americans live with chronic pain caused by a variety of conditions, injuries, or without any identifiable cause at all. Pain is considered chronic when it lasts for over six months, but it can last a lifetime for some patients. 

The individual experience of pain shapes the clinical trials on pain management. 

Clinical trial companies select a group of people who participate in clinical trials based on the underlying cause of their pain, clinical trial phase, type, or another factor. 

A person aiming to find a clinical trial on pain management can run into anything from medical surveys, early-stage paid trials for healthy volunteers, or pain management sections in studies on other diseases like migraines, diabetes, different types of cancer, or osteoarthritis.

How Do Chronic Pain Clinical Trials Work?

There are two categories of chronic pain management studies:

  • Observational studies in which the goal is to observe how patients react or deal with their current condition, without administering any treatment
  • Interventional studies or clinical trials, defined as various procedures testing different treatment options on human subjects

Clinical trials work by using the randomization method. Randomized clinical trials split test subjects into two groups. 

The first one is the control group, which could receive one of the standard treatments for chronic pain. If the researchers are using a placebo in their trial, this group gets an inactive substance. The second group gets the treatment that the researchers are testing.

The treatment/placebo arrangement has three possible scenarios:

Method Who Knows About the Treatment Arrangement
The single-blind Only the research team
The double-blind No one 
The open-label Everyone involved

It's important to note that to avoid any ethical issues in a clinical trial, patients are informed of the type of "blinding " used and other important details. 

The research team creates an ICF (clinical trial informed consent form) that clarifies any dilemmas regarding the safety of clinical trials

What Are the Phases of Pain Management Clinical Trials?

Interventional randomized clinical trials generally include four stages:

  1. Phase one is conducted to find the safest dose of the drug and usually includes only a small number of healthy volunteers
  2. Phase two serves to check if the treatment has any effect on the pain. This stage includes a few hundred test subjects
  3. Phase three is where the blinding and randomization take place, and it involves thousands of people. The goal is to compare the treatment being tested with those already available
  4. Phase four happens only if the treatment gets approval from the U.S. Food and Drug Administration (FDA). This phase can last for years, and the researchers use it to monitor participants, track their progress, and detect any long-term effects

Types of Clinical Trials for Chronic Pain

Clinical trials are testing an abundance of different drugs that can help with specific conditions, but this is not a one-size-fits-all situation. 

Cure for chronic pain, especially for the one in which the cause cannot be identified or removed, is considered non-existent.

Chronic pain trials are generally split into several categories:

  1. Screening and prevention trials are focused on testing diagnostic practices to discover the cause of chronic pain when the patient is not suffering from any particular condition
  2. Treatment trials usually aim to reduce the pain, if not eliminate it. When the condition causing the pain is incurable, the methods and drugs that decrease the intensity of chronic pain can make a significant impact on the patient’s life
  3. Quality-of-life trials are probably the most important part of pain management research. They are supposed to help patients have a relatively enjoyable life despite the pain 

Am I Eligible for “Living With Pain” Clinical Trials

The research team sets the eligibility standards for each trial, so whether you qualify mostly depends on the main focus of the research.

If you are suffering from chronic pain, chances are there is a trial you will be eligible for.

Most researchers will set the criteria such as duration of the pain, the intensity, existence/nonexistence of an underlying condition, previous treatment history, gender, or age.

If you are suffering from chronic pain, chances are there is a trial you will be eligible for. The applicants go through several recruitment stages, which means that you may be excluded during the process based on certain screening results.

How To Find the Pain Medication Clinical Trials With DoNotPay

DoNotPay is the ultimate clinical trial database that can match you with clinical trials in your vicinity, various medical studies for money, psychological surveys, the highest-paid clinical trials near you, or the pain management trials you are looking for.

Our extensive database contains an up-to-date list of drugs currently on clinical trials that you can filter out based on the distance, randomization type, placebo inclusion, compensation options, and other factors. 

We also allow you to bookmark any trial you like and set up text notifications to get an alert as soon as a new trial is posted.

Follow these steps to find the appropriate pain relief clinical trial:

  1. Open DoNotPay in your web browser
  2. Select the Clinical Trials feature
  3. Click on Get Started
  4. Adjust your filters
  5. Find a pain management clinical trial you want to join and click on it
  6. Click on Contact

DoNotPay will contact the researchers, and you can expect a reply within several days. 

You can contact as many research teams as you want and keep track of everything on the homepage. If you get accepted, you get to keep 100% of the earnings.

Other Ways To Find Pain Management Clinical Trials

Here is an overview of other trustworthy websites you can check out:

  1. The American Chronic Pain Association (ACPA) provides info to people with chronic pain. They post relevant pain management clinical trials on their website
  2. Pfizer is a biopharmaceutical company that conducts various clinical trials, including those for pain management
  3. Mayo Clinic is a reputable institution conducting numerous pain management clinical trials on its premises 
  4. ClinicalTrials is one of the largest worldwide clinical trial registries providing info on numerous chronic pain studies
  5. CenterWatch is a website focused on those trials that are actively recruiting participants
  6. ResearchMatch is a national record of clinical trials designed to match volunteers with researchers
  7. PolicyLab is a clinical trial resource center providing patients with info on available research

Learn All About Other DoNotPay's Features

DoNotPay is an administrative assistant app and an expert in finding perfect clinical trials. But we can do more than that. 

You can use our app to cancel IHC Health Solutions, United Healthcare, Oscar Health, Cheers Health, or any other service.

We make it easy to apply for clinical trials across the country, including cities like Miami, New York, and Austin

In case you plan to apply for a study far from your place of residence, take note that DoNotPay can help if any inconvenience occurs. We can show you how to get a flight cancellation refund or a flight delay compensation

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