How Do Clinical Trials Work?

Clinical Trials How Do Clinical Trials Work?

How Do Clinical Trials Work?

Clinical trials are the crucial step in exploring new treatment options, improving current ones, finding faster and more accurate diagnostic procedures, or evaluating the effectiveness of a certain medical approach. 

Clinical trials are defined as a series of research experiments on human subjects to provide insight into specific diseases and the accompanying treatment methods. 

These types of studies represent a jump from the laboratory experiments to testing on real people—whether they are healthy volunteers joining a paid trial or patients suffering from the conditions in question.

If you are looking to participate in clinical trials, it's important to get the relevant info before enrolling. 

The Basics of Clinical Trials

Clinical trials are conducted by research teams examining one particular condition, more precisely, identifying preventive measures, creating better treatments, or developing accurate screening procedures for that condition.

Based on their primary objective, clinical trials can be sorted into one of the following categories:

  1. Prevention-oriented—Clinical trials analyzing risk-factors and exploring methods to prevent the development or recurrence of a condition in question
  2. Screening-oriented—Trials and studies evaluating one or more diagnostic methods for a particular disease and searching for ways to improve early detection 
  3. Treatment-oriented—Research centered around exploring new options for treating the condition. This can include trials for new drugs, surgical methods, radiation therapy, medical devices, vaccines, etc.
  4. Wellbeing-oriented—Studies that examine ways to improve the well-being and life quality of patients by analyzing the supportive care measures

What Do Clinical Trials Look Like?

It would be dangerous to test a new treatment on many people from the get-go, so to ensure the safety of participants, trials start with smaller groups and smaller doses.

This is why clinical research is done in stages, gradually importing new elements into each of the four clinical trial phases.

Phase I

This phase ordinarily uses healthy volunteers. The purpose of the research is to determine the highest dose of the drug that the participants can take without any severe side-effects as well as the best application method.

Before this stage, researchers sometimes implement Phase 0—to make sure that the treatment is not dangerous for humans.

Phase II

Phase II is the first stage of a clinical trial that includes individuals suffering from the condition being studied. Usually, these are patients with the same diagnosis and in similar stages of the disease.

The second phase aims to determine whether the drug is making any impact on the disease and in what way. 

In cancer clinical trials, the researchers are examining if the treatment makes cancer shrink or disappear. They could also test the impact of the drugs on the recurrence of the disease. 

Phase III

Phase three implies a randomized clinical trial approach in which the participants are split into two groups. This is also the first stage to introduce the placebo (an inactive substance).

One group receives the new treatment, while the other gets either the placebo or the best known standard treatment for the disease.

The idea is to compare the effects of the new treatment to the effects of the known methods. The end goal is to check if the new treatment is better than the ones currently in use.

For the drugs to pass stage three, they have to get the United States Food and Drug Administration (FDA) approval, and almost 90 percent don't.

Phase IV

If the treatment passes stage three, it enters into the years-long process of observation. In the fourth phase, the researchers will follow up on the participants' condition, long term effects, and side-effects.

How To Sign Up for Clinical Trials With DoNotPay

If you are a patient, you'll want to find the study you are eligible for and that matches the criteria you set. As a healthy volunteer, you'll want to make sure to get paid.

We can ensure you get both of those things and do much more. 

DoNotPay is the only platform that can match you with full-scale clinical trials, but also find the perfect paid studies and research surveys.

The best part is that you can filter your search by compensation, type of trial, safety, phase, placebo inclusion, and even distance. 

We can help you locate remote trials or local clinical studies whether you live in Utah, Northern Carolina, Michigan, Atlanta, Philadelphia, Missouri, Texas, or any other state. 

Here is how DoNotPay works:

  1. Access DoNotPay from your web browser 
  2. Select the Clinical Trials option
  3. Tap Get Started
  4. Filter your search
  5. Find a clinical trial you want and click on Contact

Our app will email the research team on your behalf, and you can expect a response within several days. 

How Else DoNotPay Supports Your Through the Clinical Trial Process

Once you contact the researchers, you can keep track of your request status on the DoNotPay homepage. 

Some other features you may find useful are:

  • Bookmarks—Bookmark any trial to follow its progress. You can use this feature for upcoming studies or for those that are still recruiting if you are unsure about committing yet
  • Real-time notifications—Register to get text alerts when a new trial is posted in your area
  • No cuts on your compensation—If you enroll in a paid trial, you get to keep 100% of your earnings

Other Clinical Trials Databases

Even if you decide to look up clinical trials on your own, don't resort to googling "clinical trials near me", "paid medical surveys", or "highest-paid clinical trials near me."

There are reputable clinical trial databases and lists of drugs on clinical trials that you can check out. 

One of the most trustworthy sources for worldwide clinical studies and trials is the ClinicalTrials platform. Other, condition-specific websites use this platform as their main source of information. 

There is also the FDA's Drug Trials Snapshot page. The website offers information on clinical trials, participants, locations, and other details. 

NIH Clinical Center Search the Studies feature is another option. It is a page on the National Institutes of Health (NIH) website that has a registry of publicly supported clinical trials conducted in Bethesda.

Everything You Need To Learn About Clinical Trials' Risks and Benefits

To find a clinical trial that suits you, it's important to know what you can gain or lose by signing up for one. Regardless of the clinical study type, it's up to you to weigh the pros and cons. 



  • Access to the latest treatments for your condition
  • A chance to contribute to society as a volunteer
  • Possible positive effects on your condition
  • Constant care by high-ranking experts
  • Regular monitoring and check-up
  • Negative immediate side-effects
  • Long-term side-effects
  • Time-consuming experience
  • Unexpected costs
  • Lack of results

DoNotPay's Abundance of Possibilities

With DoNotPay, you don’t have to waste time on research or dig through the Terms and Conditions of a company to get a refund. 

We make it easy to get your money back from Walmart, Greyhound, or even Tinder. We also cancel services like Scribd or Starz

Open DoNotPay in your web browser to discover other features we offer. 

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