HIV Clinical Trials Explained

Clinical Trials HIV Clinical Trials Explained

Want To Find HIV Clinical Trials the Easy Way? Use DoNotPay!

Around 1.2 million people in the United States have HIV. Even though new medications significantly improved the life quality and expectancy of HIV-infected patients in recent decades, there is still no known cure. Numerous clinical trials across the country continue testing new therapies, possible cures, and prevention mechanisms with hopes of ending the HIV epidemic in the near future. 

HIV is an excellent example of how important participation in clinical trials is. Thanks to the years of research and countless infected and healthy volunteers, people who contract this virus can now live normal lives and keep their infection under control. 

Types of HIV Clinical Trials

Most definitions of clinical trials imply the development of new medicines or other treatment methods. While clinical trials for HIV cure play a crucial part in medical research of this global issue, there are other types of clinical studies related to HIV. 

The National Institute of Allergy and Infectious Diseases (NIAID) differentiates between five types of HIV clinical trials based on their scientific priorities:

  • AIDS clinical trials 
  • HIV prevention trials
  • HIV vaccine trials
  • Maternal, pediatric, adolescent AIDS trials
  • Microbicide trials

Depending on the methods used in the studies, clinical trials can also be:

Trial Type


Comparison studies

One test group receives the experimental treatment, while the other group gets the already-approved options
Randomized trials

Researchers randomly administer different treatments to different test subjects 

Placebo-controlled trials

One group receives the new treatment, and the other gets a placebo (a substance with no therapeutic value) without prior knowledge
Blinded trials

Volunteers don’t know which treatment they’re taking to ensure objective study results

Dose studies

Different test groups get different doses of the same treatment for comparison
Non-treatment studies

Researchers observe volunteers to gain valuable insight into HIV-related issues without testing new treatments

Phases of HIV Clinical Trials

Another factor that you should be aware of when researching HIV clinical trials near you is what trial phase you will be participating in. When tests on human volunteers begin, medical research usually involves three distinct phases with different risk levels:



Test Group Size


  • Mostly concerned with how safe the new treatment is for humans
  • Sometimes focuses on preliminary viral load reduction results during short periods
  • The highest risk of unknown side effects



  • Focused on safety and appropriate dosage
  • Further tests of effectiveness over a few months
  • Safer than Phase I 

Several hundred


  • Usually the longest stage
  • Final tests on how effective the treatment is in large groups
  • The lowest amount of risk

Up to 3,000

If the Phase III results are satisfactory, the U.S. Food and Drug Administration (FDA) grants its approval, and the treatment becomes widely available. 

Most research studies include Phase IV, which concentrates on long-term effects and other safety concerns once doctors start prescribing the new treatment to various population groups across the country and globally. 

Do I Qualify for HIV Cure Clinical Trials?

The factors determining your eligibility for HIV-related clinical trials are different for each study or clinical trial phase. While many trials require HIV-positive volunteers, so they can test the effectiveness of new treatments or move one step closer to finding the cure, some studies need HIV-negative individuals as a control group or for other purposes. 

When you find a clinical trial that looks interesting, one of the first sections in the trial description deals with clearly stated inclusion and exclusion criteria. These are some of the factors that may influence your eligibility for HIV clinical trials:

  • HIV status
  • Age
  • Gender
  • Ethnicity
  • Sexual orientation
  • Previous treatment history
  • CD4 cells count
  • Alcohol and drugs consumption

Depending on your HIV and overall health status, you should discuss participation in clinical trials with your primary healthcare provider before signing up.

How To Find HIV Clinical Trials With DoNotPay

DoNotPay understands that clinical trials are a crucial part of medical progress, but that they can also be an opportunity to earn some extra cash. Whether you’re searching for medical surveys that can be done on a computer or paid HIV clinical trials, we can guarantee you will find several options on our search platform. 

Using DoNotPay is easy and simple. To access the clinical trial search platform, set up your DoNotPay account in a web browser. When you log in, follow these steps:

  1. Select Clinical Trials
  2. Hit Get Started
  3. Adjust the search filters to show the results that match your needs
  4. Pick the study that you’re interested in
  5. Click on Contact

The recruiting staff of the study you’re eyeing will get an email conveying your interest. If you meet the preliminary screening criteria, they will get back to you within several days and let you know what you need to do next. 

Why Is DoNotPay’s Search Platform Better Than Others?

DoNotPay offers fully customizable search filters making sure you see only the trials you can apply for. You can browse our vast database based on your age, location, trial safety, potential compensation, pregnancy status, and other individual preferences. 

Additional useful features of our search platform include:

  1. Possibility to bookmark studies and save them for later
  2. Tracking the progress of upcoming clinical trials within the app, so you can apply as soon as the recruitment process starts
  3. Text message notifications for new trials
  4. Constant real-time updates with new studies on your homepage
  5. No cuts or fees—everything you earn from participation belongs to you

You can use DoNotPay to find clinical trials for cancer, rheumatoid arthritis, diabetes, depression, or studies conducted by famous research companies like PPD, Worldwide, Quintiles (IQVIA), and others. 

How Safe Are HIV Clinical Trials?

Every medical procedure comes with a certain risk. While it’s true that clinical trials pose a greater risk because they are the first time human subjects come in contact with new treatments, there are multiple safeguards that minimize adverse events. 

Before the trials begin, new treatment options go through extensive preclinical research in laboratories. Sometimes researchers test them on animals first to ensure they’re generally safe for living beings. Even though scientists cannot predict all possible side effects in the human body, they can have a good guess about what can go wrong and how to stop it. 

Additional built-in mechanisms that each clinical trial must have are:

  • Informed consent procedure where the recruiters must provide all necessary information (risks, benefits, test procedures, expectations, etc.), so volunteers can make an informed decision
  • Institutional Review Board (IRB) that protects volunteers’ rights and reviews the safety standards
  • Data and Safety Monitoring Board (DSMB) that includes independent experts who review trial data and can shut down the study if the safety of participants is endangered 

Additional Resources for Finding HIV Clinical Trials

There are many verified platforms and websites where you can find more information on the newest studies and what participation in HIV clinical trials entails. Some of them are:

  1. HIV Prevention Trials Network (HPTN)
  2. Treatment Action Group (TAG)
  3. HIV Vaccine Trials Network (HVTN)
  4. ClinicalTrials
  5. ResearchMatch
  6. CenterWatch

Can I Use DoNotPay for Other Issues?

DoNotPay helps you find clinical trials anywhere, whether you live in Boston, Denver, or San Diego, but you can use our app as a great resource for fighting various bureaucratic battles. 

Access DoNotPay from any web browser and explore other tools that will help you thrive despite the burdens of everyday life: 

Want your issue solved now?