Molecular Scissors and Pasting Tools—CRISPR Clinical Trials
The concept of gene therapy has been around for a few decades, but CRISPR gene therapy has revolutionized the medical field.
As it is a promising form of treating many serious illnesses, many CRISPR clinical trials are underway, and more are yet to come.
If you or someone close to you are considering participating in clinical trials or medical surveys in the field of CRISPR gene editing, DoNotPay can help you learn more about it and find the clinical trial suitable for you.
What Is CRISPR?
CRISPR, or Clustered Regularly Interspaced Short Palindromic Repeats, are DNA sequences making the immune system of bacteria. CRISPR-Cas 9 is a gene-editing technology based on that immune system.
The CRISPR gene-editing tool consists of two components:
- The Cas 9 protein that can cut DNA
- A guide RNA that contains the DNA sequence to be edited
The guide RNA binds to the Cas 9 protein and directs it to the targeted DNA location. Once there, the Cas 9 cuts the DNA with extreme precision and shuts the gene off. Harnessing the self-repairing power of the cell, researchers can add or delete genetic material as well as introduce a customized DNA sequence.
You can check out this YouTube video to see how the CRISPR system works.
What Types of CRISPR Clinical Trials Are There?
The current CRISPR clinical trials focus on the therapeutic aspect of the CRISPR system, though there are the ones focused on disease prevention and diagnostics.
How Do CRISPR Clinical Trials Work?
How CRISPR clinical trials work depends on the type of the trial, but what all trial types have in common is using the enhanced CRISPR system tools to target the desired disorder or mutation.
Treatment CRISPR clinical trials revolve around testing CRISPR gene-based therapies to treat or, eventually, cure genetic disorders, like sickle-cell disease, or acquired conditions, such as cancer—lung cancer or melanoma—HIV infection, or heart diseases.
The most common treatment strategy researchers test in clinical studies is ex vivo, but as of recently, there has been an increasing interest in the in vivo strategy, too.
Ex Vivo Treatment Strategy
Ex Vivo approaches involve editing genes in patient-derived cells. It means that researchers harvest cells from the patient, reprogram them to recognize and change a specific sequence in the targeted cell’s genetic code, and transplant them back to the patient.
In Vivo Treatment Strategy
In CRISPR in vivo therapy, researchers directly inject CRISPR-Cas 9 components carried by vectors (viral or non-viral) into the patient for in situ gene editing.
CRISPR Clinical Trial Phases
CRISPR clinical trials in the U.S are mostly focused on treatment and currently in their:
- Phase I—assessing the safety and treatment dosage as well as a body reaction
- Phase II—testing the treatment efficacy, distribution, and short-term side effects
Are CRISPR Clinical Trials Safe?
Each clinical trial comes with certain risks, but the consensus is that CRISPR studies are worth the shot. Since all clinical studies require FDA approval, CRISPR clinical trials have to be in line with the strictest rules and regulations, too.
One of the greatest challenges is the CRISPR-Cas 9 delivery to the desired genome site during in vivo gene editing. Even if the targeted genome cuts are made, researchers are unsure whether the CRISPR system will perform as programmed or make rogue alterations.
Delivery does not pose such a huge problem for ex vivo gene therapies since researchers can monitor the changes and check for problems before administering the treatment to patients.
Compared to conventional gene therapies, CRISPR is more precise. Confirming the body reaction to DNA changes lies in future studies, though preliminary results of ex vivo cancer treatment studies are promising, making CRISPR clinically feasible and safe.
Why Are CRISPR Clinical Trials Important?
CRISPR-Cas 9 can revolutionize diagnosing, treating, and preventing diseases and illnesses.
These studies are important to assess the safety and efficacy as well as short and long-term effects of this gene-editing technology.
Does CRISPR Have Any Other Application?
Yes, it does—in agriculture. CRISPR has already found its application in food production to create enhanced foods resistant to viruses and bacteria.
Find and Apply for a CRISPR Clinical Trial With DoNotPay
You have set out to find and apply for clinical trials in your area, but Google generates too many results, and you don’t know what clinical trial databases are trustworthy? Rely on DoNotPay, and all your problems with the search for clinical trials are gone.
DoNotPay’s search platform is where you can find numerous clinical trials organized or backed by diverse renowned research organizations. Its design enables you to browse for studies based on:
- Individual preferences (placebo inclusion, observational studies, medical surveys, and more)
This user-friendly search tool allows you to apply for an unlimited number of trials and even change your preferences or settings.
To see how the platform works, sign up with DoNotPay in your web browser and follow the instructions listed below:
- Go for Clinical Trials
- Tap Get Started
- Adjust the search filters
- Select the study you are interested in
- Hit Contact
When we receive your request, we will contact the research institution behind the clinical trial you have chosen. What we will do is sign you up and provide details about your eligibility, enhancing your enrollment prospects. The research staff will contact you with information about the next course of action.
Extra DoNotPay Search Tool Perks
Our search tool comes with additional advantages listed in the table below:
Status tracking system
Worth mentioning is the fact that DoNotPay won’t charge any fees for the paid clinical trials you participate in—the compensation you get is yours in its entirety.
DoNotPay Helps Right Away
Like CRISPR, DoNotPay is versatile in its own right.
Our app provides you the best enrollment opportunities for trials focused on diverse conditions, including AML, Lupus, or Alzheimer’s Disease. If looking for something more eccentric, we can help you locate trials testing LSD or other psychedelic drugs.
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