Win the Fight and Help Others by Participating in AML Clinical Trials

Acute myeloid leukemia (AML) is a cancer of the bone marrow. It’s a disease that, on average, affects people who are 65 or older. This disease can progress rapidly if untreated. Because of this, researchers are studying new ways to find a cure for AML and conducting clinical trials to test potential new treatments. 

Learn About Clinical Trials for Acute Myeloid Leukemia

Acute myeloid leukemia is a type of cancer that starts in the bone marrow, disrupts normal blood cell production, and often moves into the blood. It can spread to other parts of the body, such as the liver, spleen, and testicles. Symptoms of AML vary from swollen liver and spleen to discomfort in bones or joints. There are three that, if present, are dangerous without treatment:

  1. Myeloid sarcoma—happens when the AML mass forms and creates a tumor elsewhere in the body
  2. Infections—happens when your body doesn’t produce enough white blood cells
  3. Brain or lung bleeding 

Some symptoms of AML are similar to other serious diseases, so the doctors use a few tests to diagnose it:


Tests Details

Bone marrow tests

  • Obtaining samples of bone marrow in a two-step process. Both steps are  happening at the same time 
  • Looking for chromosomal and other cell changes
  • Getting bone marrow samples from the hip bone

Blood tests

  • Taking the blood from the vein
  • Using a complete blood count and peripheral blood smear to look for AML

Genetics test 

  • Changes in the genes or chromosomes of a cell to help identify AML
  • Using three different tests

For some of the patients, AML or some subtypes of AML are curable with current treatments. Still, researchers test new drugs or procedures to help find a cure for the subtypes of AML that can’t be treated successfully yet. 

Current AML Leukemia Clinical Trials

Taking part in a clinical trial tends to be a bit more complicated than a person would assume. Every clinical trial has four phases:

  1. Phase I— Finding the best dose of a new drug with as little as possible side effects. Doctors give a small amount of the drug to the patients. The number of participants is 20 to 30
  2. Phase II—Testing the safety and efficiency of the drug. The drug is tested on patients with a subtype of AML. The number of participants is around 100
  3. Phase III—Comparing the new drug with the existing one. These trials determine the side effects of each drug and decide which one works the best. The number of participants ranges from 100 to 1,000
  4. Phase IV—Researchers in this phase gather information about the long-term effects of the drug. This phase is crucial for the FDA approval of the drug

Clinical trials for AML do not accept healthy volunteers, which means you need to have AML to be a part of one. Current clinical trials for AML include:

Trials Approach
Monoclonal antibody treatment Researchers use specific antigens, including CD33, which is present in most AML cells  
CAR T-cell therapy A type of immunotherapy in which scientists take immune cells from patients’ blood and alter them in the laboratory to produce chimeric antigen receptors (CARs). The cells containing CARs are then returned into the patients’ system to fight cancer cells
Vaccine therapy Researchers are developing vaccines that can be personalized to the individual patient 
Immunotherapy Scientists use materials either made by the body or made in the laboratory to boost or suppress the immune system to help it fight cancer 

Find Clinical Trials for AML With DoNotPay

If you are having a problem finding clinical trials and googling “clinical trials near me” isn’t helping, DoNotPay is here to help you. Aside from clinical trials, our database includes university psych studies and medical surveys. DoNotPay can help you find a clinical study you want, regardless of how fastidious you are.

In your search for AML, you can specify individual preferences—from the location of the study to the type of trial. Follow our step by step guide to finding the best study for AML:

  1. Open DoNotPay in a web browser
  2. Click Clinical trials
  3. Tap Get started
  4. Set the filters
  5. Choose the AML trial you like
  6. Click Contact

Once you make a contact request, we will send an email to the researchers, and you can expect a response in a few days. You can find as many trails as you want, and you can do so free of charge. We also have a real-time notification that can tell you if a new drug is being tested and if researchers are recruiting.

Why Participate in AML Clinical trials?

Before deciding if the AML clinical trial is the right choice for you, you should talk to your physician. Before you decide, consider the disadvantages and the benefits involved:

Benefits

  • Access to new drug and treatment
  • Taking an active role in your health
  • Enhanced cancer care
  • Helping others 
  • Reducing cost for treatment of AML 
  • Close monitoring by doctors in charge

Disadvantages

  • Not being able to choose the group you are in
  • Treatment might not be as effective for some patients
  • Using the placebo
  • Getting severe side effects
  • Having more mandatory checkups

How Much Time Does an AML Clinical Trial Take?

Every phase of the trial lasts a different amount of time, but all together, AML clinical trials can take up to ten years. Here is the expected duration of each phase:

Phase Duration time
Preclinical research  One to six years
Phase I Several months
Phase II Several months to two years
Phase III One to four years

Other Options You Can Look Into Before Applying for an AML Clinical Trial

Plenty of people decide to participate because they hope to get cured, and if you are one of those people, you should look into other options as well:

  • Chemotherapy and drug therapy—chemotherapy is the use of potent drugs to kill or damage cancer cells. Treatment is done in two phases—induction therapy and post-remission therapy
  • Stem cell transplantation—this is used combined with the second phase of chemotherapy. After chemotherapy, patients receive an infusion of stem cells to replace destroyed stem cells. There are two main types of stem cell transplantation—using stem cells from a patient and using stem cells from a healthy donor

Alternative Ways of Finding Clinical Trials for AML Leukemia

The alternative for finding clinical trials for AML are official sites that are trustworthy:

Site Features

ClinicalTrials

  • Provided by U.S. National Library of medicine
  • Has over 350,000 studies
  • Search in over 50 countries 

NIH

  • Use advanced search
  • Search by age, zip code, and keyword

Leukemia&LymphomaSociety

  • Has financial and community support
  • Support over phone and email

How Else Can DoNotPay Be of Service to You?

Besides finding AML clinical trials for you, our app can help you look for trials for diseases such as HIV, breast cancer, lung cancer, and many more. Our database is huge, and you can find the best clinical trial for you regardless of your (or their) criteria. If one of your search filters is the location of clinical trials for acute myeloid leukemia, you don’t have to worry. With our platform, you can find AML clinical trials in San Diego, Las Vegas, and many more. 

Open DoNotPay in your web browser and have a look at all types of services we can help you with: