ALS Clinical Trials Explained

Clinical Trials ALS Clinical Trials Explained

Why Are ALS Clinical Trials Important and How To Find the Right One?

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive neurodegenerative disorder that leads to the loss of nerve cells in the brain and spinal cord. 

Over 5000 Americans receive an ALS diagnosis each year. The total number of patients living with the condition that could lead to muscle weakness and atrophy, as well as cognitive impairment, is estimated at 20,000. 

ALS has been in the media spotlight for a while now, but despite that, there are only four ALS drugs approved by the U.S. Food and Drug Administration (FDA). 

This is why participating in clinical trials and medical surveys is crucial for the development of further treatments and a potential cure for ALS.

What To Expect From Clinical Trials for ALS?

This depends on what type of clinical study or a clinical trial you want to participate in. 

ALS research can be conducted using two main methods: observational studies and interventional trials.

Here are the main differences between the two:

Observational Studies

Interventional Trials—Clinical Trials

  • Participants are patients at a certain stage of ALS
  • No additional treatment is administered by the research team
  • The goal is to observe and analyze a certain characteristic, which will help develop concepts on how to treat the disease
  • Done in stages
  • Participants can be patients or healthy volunteers joining a paid trial, depending on the stage
  • The goal is to test a new treatment—whether it's safe, effective, and better than the alternatives

ALS research studies that fall under the interventional category are generally randomized clinical trials, which means that the subjects are split into two groups: one that receives a new treatment and another that gets the placebo.

The research team can opt to manage the group using one of three approaches:

  • The single-blind—Only the researcher knows who gets the treatment and who gets the placebo
  • The double-blind—No one is familiar with which group gets what treatment
  • The open-labelEveryone is informed about the treatment program

Why You Should Participate in the ALS Clinical Trials

Whatever option you choose, there are many benefits of participating in ALS CLinical trials.

One of the reasons to participate is to gain access to the latest treatments science can offer. As clinical trial participants are monitored closely, you will get top-notch healthcare during the process. 

There are risks of side-effects, but you will get a chance to help yourself and pave the road for others dealing with ALS. 

How To Find a Clinical Trial for ALS

When searching for an ALS clinical trial, you have to consider various factors such as duration, location, the type of drug being tested, your physical condition, and the stage of the disease.

ALS patient trying to find a clinical trial that fits their criteria has a few choices:

  1. Rummaging through clinical trial databases to find a trial they are eligible for—some reputable websites are ClinicalTrials, NIH Clinical Center, ALS Therapy Development Institute, and ALS Association
  2. Checking the FDA and other websites for a list of drugs currently in clinical trials
  3. Googling "clinical trials near me" and hoping for the best

Time is of the essence, so endlessly browsing the internet won’t get you the results you are hoping for. 

This is why you should use DoNotPay to find a suitable clinical trial without wasting any time. DoNotPay is the only platform that will match you with the ALS trials you’re eligible for based on your preferences, using a fully customized matching algorithm. 

How To Sign Up for ALS Clinical Trials With DoNotPay

DoNotPay lets you find the trial you want within minutes. 

You can choose between clinical trials, university studies, and paid research surveys, all according to the filters you set up. 

You can customize your search to match different criteria, including compensation range, safety, distance, randomization, the inclusion of placebos, and more. You can change these settings anytime you want.

Follow these steps to find the ALS study you want:

  1. Access DoNotPay in your web browser
  2. Pick the Clinical Trials feature
  3. Tap Get Started
  4. Arrange your filters
  5. Pick the ALS trial that you want to join
  6. Tap Contact

We will email the researchers on your behalf, increasing your chances of admission. You can repeat this process for as many times as you like and sign up for any trial.

DoNotPay allows you to keep track of the studies you contacted and bookmark any upcoming study on the homepage. You can also set up notifications when new studies show up.

What Stages Do ALS Clinical Trials Have?

You can define any clinical trial as a research process meant to discover the impact of treatment on the human test subject. This is a long and complex process, and the end goal is to get the treatment approved by the FDA, but most drugs never reach that stage. 

Every potential ALS treatment has to go through three to five phases of a clinical trial, the first one being the preparatory stage.

The phases of ALS clinical trials are:

  1. The initial preparatory phase is conducted on a small number of participants. The point is to make sure that the experimental treatment is not harmful to humans, which is why researchers use a minimal dose of the drug
  2. Phase I is usually conducted on healthy individuals. The goal is to make sure that the drug is safe, more precisely, to find the safe dosage and application method. FDA states that approximately 70 percent of drugs pass this phase
  3. Phase II includes people who have been diagnosed with ALS. They receive approximately the same dosage established as safe in the previous phase. The goal is to see if the medication is effective and in what way
  4. Phase III can last for several years and involve thousands of people. This is where randomized studies show up. The purpose is to show if the new treatment is better than the best-known treatment offered on the market. The end goal is to get an FDA approval, which happens in roughly 25 to 30 percent of cases
  5. Phase IV involves thousands of participants and lasts for many years. It's a data-gathering phase focused on getting to the bottom of medication’s long-term side-effects and safety

DoNotPay—All the Fantastic Options!

DoNotPay is a digital assistant app specialized in making your everyday tasks easy. 

We cut out all the nonsense—whether you want to sign up for clinical trials, get rid of spam emails, make money off robocalls, or request a refund from any company. 

We can also cancel any service for you—Pantaya, Slack, Skillshare, Zoosk—all gone with a few clicks. 

To discover other amazing features our app offers, open DoNotPay in your web browser and check out how we can assist you with:

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